Role of Notch signaling during lipopolysaccharide-induced preterm labor

Role of Notch signaling during lipopolysaccharide-induced preterm labor.

Notch signaling pathways exert effects throughout pregnancy and are activated in response to TLR ligands. To investigate the role of Notch signaling in preterm labor, Notch receptors (Notch1-4), its ligand Delta-like protein-1, transcriptional repressor hairy and enhancer of split-1, and Notch deregulator Numb were assessed. Preterm labor was initiated on gestation d 14.5 by 1 of 2 methods: 1) ...

Notch Signaling in Inflammation-Induced Preterm Labor

Notch signaling plays an important role in regulation of innate immune responses and trophoblast function during pregnancy. To identify the role of Notch signaling in preterm labor, Notch receptors (Notch1-4), its ligands (DLL (Delta-like protein)-1/3/4), Jagged 1/2) and Notch-induced transcription factor Hes1 were assessed during preterm labor. Preterm labor was initiated on gestation day 14.5...

Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice.

IL-10 is highly expressed in the uterus and placenta and is implicated in controlling inflammation-induced pathologies of pregnancy. To investigate the role of IL-10 in regulating preterm labor, the response of IL-10 null mutant mice to low-dose LPS in late gestation was evaluated. When IL-10 null mutant C57BL/6 (IL-10(-/-)) and control (IL-10(+/+)) mice were administered LPS on day 17 of pregn...

Lipopolysaccharide-Induced Preterm Labor Essential Role for IL-10 in Resistance to

P-179: The Role of Fetal Sex on Preterm Labor

Background: Preterm labor is a major problem in obstetric practice. Rates of preterm birth vary between different populations and ethnic groups. In maternal fetal medicine, gender differences in outcome are often observed. Epidemiologic studies have suggested that the incidence of preterm birth is also higher in pregnancies carrying a male fetus. The purpose of this article is to review the evi...